Based on the analysis for biology and medicine, we propose strategies for constructing a sensing interface and apply it to the research fields of nanoelectrodes, stretchable electrodes and liquid biopsy.
All cell species are exposed to the mechanical cues existing in the microenvironment, and their biochemical response is highly related to these mechanical stresses imposed on them. However, conventional rigid sensors still have large restriction on characterizing the biomolecules released from dynamic deformed cells or soft tissues due to the lack of conformable interface. To this respect, we h...
Numerous fundamental biological processes occur in subcellular locations or inside intracellular organelles. Nanoelectrodes allow precise and quantitative measurements of important biomolecules at the single living-cell level in real time. We are devoted to designing novel strategies for nanoelectrodes fabrication to explore unclear subcellular biological processes. We have developed carbon fib...
Circulating tumor cells (CTCs) are traveling cells in physiological fluids which are shed from cancerous tumors, enter the circulatory system, and migrate to distant organs to form metastases. Detection of CTCs from peripheral blood, as a "liquid biopsy", represents a reliable potential alter-native to routine cancer diagnostics, however, extremely low abundance (a few to hundreds CTCs among 10...
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