ABSTRACT：Nanoelectrochemistry is widely recognized as a powerful tool for in situ studying processes at nanoscale. However, the exiting strategies for nanoelectrodes preparation usually suffer from limited variety of electrode materials, time-consuming fabrication procedures and difficulties in functionalization. Herein, we propose a novel strategy for one-pot and large-scale synthesis of functionalized core-shell nanowires (NWs) to high-efficiently construct single nanowire electrodes. Based on the polymerization reaction between 3,4-ethylenedioxythiophene (EDOT) and noble metal cations, manifold noble metal nanoparticles-polyEDOT (PEDOT) nanocomposites can be uniformly modified on the surface of any nonconductive NWs. This provides a facile and versatile approach to produce massive number of core-shell NWs with excellent conductivity, adjustable size, and well-designed properties. Nanoelectrodes manufactured with such core-shell NWs exhibit excellent electrochemical performance and mechanical stability as well as favorable antifouling properties, which are demonstrated by in situ intracellular monitoring of biological molecules (nitric oxide) and unraveling its relevant unclear signaling pathway inside single living cells. This work provides a brand new idea for facile construction of high-performance functionalized nanoelectrodes, which is of great benefit for the research on nanoscale processes.

DOI: 10.1002/anie.202106251