Abstract: Electrochemical sensing based on conventional rigid electrodes has large restriction on characterizing the biomolecules of deformed cells or soft tissues. The recent emergence of stretchable sensors allows them to conformally contact to curved surface and perfectly comply with the deformation of living cells and tissues. This provides a powerful strategy to monitor biomolecules from mechanically deformed cells, tissues and organisms in real time, and opens up new opportunities to explore the mechanotransduction process. In this minireview, we first summarize the fabrication of stretchable electrodes with emphasis on the nanomaterial‐enabled strategies. We then describe representative applications of stretchable sensor in real‐time monitoring of mechanically‐sensitive cells and tissues. Finally, we present the future possibilities and challenges of stretchable electrochemical sensing in cell, tissue and in vivo detection.

DOI:10.1002/anie.202007754